Car T Cell Therapy Lymphoma Side Effects

Car t cell therapy side effects.

Car t cell therapy lymphoma side effects.

Neurologic events can also be experienced and can be serious in some patients. Neurologic events include encephalopathy. Cytokine release syndrome crs you may have heard of the cytokine storm in 2018 when many people got seriously ill during flu season. Cytokine release syndrome which is similar to flu like symptoms headache.

What are the side effects of car t cell therapy in lymphoma patients. As the car t cells work to fight cancer they cause the release of large amounts of other t cells into the blood along with cytokines which are proteins released by cells that communicate to other cells that there s a job to be done. Some people have had serious side effects from this treatment especially as the car t cells multiply in the body to fight the cancer. Low white blood.

Car t cell therapy involves extracting a cancer patient s white blood cells and reprogramming the t cells the roving warriors of the immune system with an antibody like protein called chimeric antigen receptor or car. The possible side effects that your doctor will discuss with you include. The most common side effects seen are. The resulting onslaught can produce dangerously high fevers extreme fatigue difficulty breathing and a sharp drop in blood pressure.

Some side effects can be severe or fatal. While the therapy can lead to long lasting remissions for some patients with very advanced cancer it can also cause neurologic side effects such as speech problems tremors delirium and seizures. Once they enter the body car t cells initiate a massive release of proteins called cytokines which summon other elements of the immune system to join the attack on tumor cells. Common side effects of car t cells which can affect more than 1 in 5 people include.

The modified cells are returned to the patient s body a process that takes less than 10 minutes. Serious side effects of this release can include very high fevers and dangerously low blood pressure in the days after treatment is given.